Serum C3 levels in acute glomerulonephritis and postnephritic children.
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چکیده
منابع مشابه
Glomerular deposition of properdin in acute and chronic glomerulonephritis with hypocomplementemia.
Kidney tissue from 97 patients was studied by immunofluorescent techniques using antiserum to purified properdin. All patients with acute poststreptococcal glomerulonephritis showed deposition of properdin and the third component of complement (C3), either as "humps" on the basement membrane, or in the mesangium. In all cases of chronic membranoproliferative glomerulonephritis, properdin and C3...
متن کاملAcute Presentation and Persistent Glomerulonephritis Following Streptococcal Infection in a Patient With Heterozygous Complement Factor H–Related Protein 5 Deficiency
Acute poststreptococcal glomerulonephritis is a common cause of acute nephritis in children. Transient hypocomplementemia and complete recovery are typical, with only a minority developing chronic disease. We describe a young girl who developed persistent kidney disease and hypocomplementemia after a streptococcal throat infection. Kidney biopsy 1 year after presentation showed isolated glomeru...
متن کاملآیا مصرف آنتی‌بیوتیک از شدت تظاهرات بالینی گلومرولونفریت متعاقب استرپتوکوک می‌کاهد؟
Background & Aim: Antibiotic treatment prevents new episode of Acute Post Streptococcal GlomeruloNephritis (APSGN). In this study we evaluated the correlation of antibiotic therapy and the severity of APSGN in children. Patients and Methods: Between 1989 and 2001, files of all patients with diagnosis of glomerulonephritis were reviewed retrospectively. Inclusion criteria were: 1- hematuria,...
متن کاملCirculating immune complexes and complement levels in relation to the clinical presentation of Nigerian children with acute poststreptococcal glomerulonephritis.
Circulating immune complexes have been detected in the sera of 24 Nigerian children with acute poststreptococcal glomerulonephritis using two methods. There was a significant correlation between levels of soluble complexes, detected in samples taken from patients in the oliguric phase of acute nephritis, and severity of disease, as judged by blood urea levels. Serial estimation of immune comple...
متن کاملEculizumab for dense deposit disease and C3 glomerulonephritis.
BACKGROUND AND OBJECTIVES The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the alternative complement pathway. Eculizumab, a monoclonal antibody that binds to C5 to prevent formation of the membrane attack complex, may prove beneficial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS In this open-label, proof of concept efficacy and safety study, six s...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 48 8 شماره
صفحات -
تاریخ انتشار 1973